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KMID : 0191120220370210168
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Journal of Korean Medical Science
2022 Volume.37 No. 21 p.168 ~ p.168
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Positivity of Rapid Antigen Testing for SARS-CoV-2 With Serial Followed-up Nasopharyngeal Swabs in Hospitalized Patients due to COVID-19
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Kweon Oh-Joo
Lee Joo-Hee
Choi Yang-Seon
Kim Boo-Seop
Lim Yong-Kwan
Lee Mi-Kyung
Park Joung-Ha
Park Ji-Young
Kim Seong-Hwan
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Abstract
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Despite the accuracy of nucleic acid amplification tests (NAATs), rapid antigen tests (RATs) for severe acute respiratory syndrome coronavirus-2 are widely used as point-of-care tests. A total of 282 pairs of reverse transcription-polymerase chain reaction and Standard Q COVID-19 Ag tests were serially conducted for 68 patients every 3?4 days until their discharge. Through a field evaluation of RATs using direct nasopharyngeal swabs, the sensitivities were 84.6% and 87.3% for E and RNA-dependent RNA polymerase (RdRp) genes, respectively, for specimens with cycle thresholds (Cts) < 25. The Ct values of E and RdRp genes for 95% detection rates by RATs were 16.9 and 18.1, respectively. The sensitivity of RAT was 48.4% after the onset of symptoms, which was not sufficient. RAT positivity gradually decreased with increased time after symptom onset and had continuously lower sensitivity than NAATs.
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KEYWORD
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Antigen Test, COVID-19, Nucleic Acid Amplification Techniques, SARS-CoV-2
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